15 Natural Anti-Histamines & Mast Cell Stabilizers (2022)



In functional medicine, we always want to be looking upstream and trying to gather as many clues and evidence through testing and intake to determine what is at the root cause of the chronic symptoms in question.

We then work to treat and resolve the underlying problem(s) and this helps to reduce symptoms and restore health long term. But what happens when someone is reacting to or not tolerating the treatment needed to resolve their root cause problems?

This is the biggest challenge I see for those who have MCAS and histamine intolerance. Their immune systems are so hyper-reactive and overly sensitive that they will often have trouble tolerating the treatment needed to resolve the root cause issues like parasites, lyme, SIBO, retroviruses, or mold.

I experienced this personally when I was being treated for Lyme disease and mold illness aggressively for 2 years before knowing that MCAS was playing a role in my symptoms.My MCAS manifested as extreme body pain, even after 2 years of Lyme disease treatment my pain wasn't getting any better, in fact, it was getting worse!! I also found myself becoming very sensitive and reactive to foods, smells, chemicals, EMF's, and even most of the medications and supplements that were treating my illness. I could not tolerate treatment and was just getting sicker and feeling worse.

​Figuring out I had MCAS and adding in bothpharmaceutical and natural anti-histamines and mast cellstabilizers was a gamechanger for me. My pain levels dropped slowly, my energy improved, my rashes disappeared and my food reactions lessened. Overtime Ifinally started to be able to tolerate thetreatment I needed toresolve my root


After my personal experience and professionally working with lots of mast cell clients, I now understand that its imperative to get the immune system to calm down and be less reactive before you will be able to tolerate treatment for and resolve what's at the root cause of your MCAS.

My practice is now 90% MCAS patients and every client is unique in what combination of anti-histamines and mast cell stabilizers work to calm down the immune response and be less reactive.

I use special lab testing to help give me clues about each clients bio-individual triggers, metabolism, and root cause issues. This helps me make educated recommendations in the area of natural anti-histamines and mast cell stabilizers that will work for each personal individually.

There are some nuances to choosing the right combination of supplements and it often takes some trail and error. This is why I highly recommend working with a practitioner who knows and understands this well to help guide your choices.

You will want to choose clean formulations with minimal or no fillers. I suggest single active ingredient items so that you know what is helping or hurting you.

If you are someone who has food reactions, you will want to time these items to be taken 15-30 minutes prior to meals. This timing can help to reduce post meal time mast cell reactions.

Lastly, never try more than one of these at the same time. Always try anything that is new to you alone with no other changes or adjustments in food or medications, titrate up to the recommended dose (or your tolerated dose) slowly and then add the next item. I typically recommend a 3 day trial before increasing the dose or adding the next supplement.

Here are the natural options that I use most in my practice...

15 Natural Anti-Histamines & Mast Cell Stabilizers:
  1. Quercetin - a bioflavonoid that is likely the most used and well known anti-histamine and natural mast cell stabilizer. It is sourced from either citrus or onion &garlic family. Tip: People who have salicylate intolerance will sometimes not toleratequercetin well.
    Recommended Brands: Pure Encapsulations Quercetin
    Recommended Dose: Start with 250mg once/day and work up to 500mg 3 times/day
  2. Luteolin - abioflavonoid that is usually extracted from artichokes that is a potent mast cell stabilizer and natural anti-histamine. I find it works well to reduce neurological symptoms like anxiety, insomnia, irritability, fatigue and brain fog.
    Recommended Brands: Young Nutraceuticals Mirica, Mirica Advanced, & Luteolin Complex*
    Recommended Dose: Start with 25mg once daily and work up to 25-50mg 3 times/day

    *To order Mirica, Mirica Advanced, or Luteolin Complex, click here.

  3. Perilla Extract -comes from perilla seed and the extract contains two potent ingredients: luteolin and rosmarinic acid that have the ability to modulate Th2 cytokines to reduce hyper-sensitivity. You already know that luteolin is an effectivemast cell stabilizer but did you know rosmarinic acid is a potent anti-viral?In fact, rosemarinic acid has been shown to be effective against COVID-19. Perilla seed extract works on mucus membranes, so it can help with lung inflammation and asthma as well other mucosal membranes like the sinuses and gut. It has also been shown to help people sweat and can help reduce muscle spasms.
    Recommended Brand: Pure Encapsulations Perilla Extract
    Recommended Dose: Start with150mg once daily and work up to 300mg 3 times/day
  4. Pycnogenol - is pine bark extract,anotherbioflavonoid that can be effective as a mast cellstabilizer and anti-histamine. This is often a good choice when quercetin and/or luteolin are not tolerated well which is fairly common as this uses a different liver pathway compared to quercetin and luteolin so those who are phenol sensitive may tolerate this better.
    Recommended Brand: Pure Encapsulations Pycnogenol
    Recommended Dose: Start with 50mg once daily and work up to 100mg 3 times/day
  5. Fisetin - another potent bioflavanoid that is a mast cell stabilizer but also has anti-coagulant properties. This means it can help to improve blood flow which helps to oxygenate your cells, improves nutrient absorption, and makes detoxification more effective. It has been shown to help reduce neurological inflammation and is neuro-protective.
    Recommended Brand: Life Extension Bio-Fisetin
    Recommended Dose: Start with 1 capsule/day and work up to 1 capsule, 3 times/day
  6. Stinging Nettles Leaf-has been shown to inhibit leukotriene release from mast cells. Leukotrienes are a mediator that often gets triggered from salicylate and phenol sensitivity. It can also help to reduce lung inflammation and asthma as well as skin rashes and itching. I've also clinically observed that it tends to help with irritability and anxiety as well!
    Recommended Brand: Gaia Nettle Leaf
    Recommended Dose: Start with 250mg once daily and work up to 500mg 3 times/day
  7. Vitamin C - can be effective as an anti-histamine, however I find that ascorbic acid products are not often well tolerated by MC patients so I typically recommend that clients try a Vitamin C sourced from tapioca.
    Recommended Brand: Ecological Formulations Vitamin C-1,000
    Recommended Dose: 1,000mg up to 3 times daily
  8. Evening Primrose Oil - has been shown to lower prostaglandins which are another mediator that gets released from mast cells. I find it helps with sleep, anxiety, and sometimes pain.
    Recommended Brand: Body Bio Evening Primrose Oil
    Recommended Dose: 1,500mg once daily at bedtime
  9. DAO Enzyme or Xylanase Enzyme -while these enzymes are not mast cell stabilizers or anti-histamines, they do help to break down histamine and phenol based compounds in the gut and can be effective in reducing reactions to foods especially.

    DAO is used for those who have histamine intolerance and a mutation on their DAO or HNMT enzymes. I like Diem Histamine Digest**, formerly called Umbrellex brand DAO. I find this formulation to be the cleanest of all the DAO products out there.
    Recommended Dose: 1 capsule prior to each meal.

    **To order Diem Histamine Digest, click here.

    Xylanase is an enzyme used to help break down phenol based compounds like salicylates that many mast cell people are reactive to.
    Recommended Brand:Houston Enzymes No-Fenol (available on Amazon)
    Recommended Dose: 1 capsule prior to each meal

  10. Milk Thistle - is a natural mast cellstabilizer, also helps to support liver and gallbladder detox. This is not recommendedfor those that have a ragweed allergy.
    Recommended Brand: Gaia Brand
    Recommended Dose: 400mg twice daily
  11. Butterbur - this is a natural anti-histamine that workssimilarly to H1 blockers Zyrtec or Allergra. This can be especially helpful for brain related symptoms like brain fog, anxiety, and migraines.
    Recommended Brand: Integrative Therapeutics Petadolex
    Recommended Dose: 50mg 2-3 times daily
  12. Feverfew - this is a natural mast cellstabilizer thatsupports healthy mucous membranes and canimprove cranial bloodvessel integrity. It can be veryeffective for headaches andmigraines related to mast cell and histamine issues.
    Recommended Brand: Vital Nutrients Feverfew
    Recommended Dose: 1-2 capsules up to twice daily
  13. Baical Skullcap(Chinese Skullcap)- This herb can bevery helpful in loweringneurological inflammation and can help with insomnia, anxiety, and depression. It is a natural mast cell stabilizer and helps to de-activate retroviruses which I find to be a big root cause of MCAS.
    Recommended Brand: BioPure Chinese Skullcap, Liftmode Biaclin, & Secrets of the Tribe Huang-Qin Alcohol Free Tincture (you can find these all on Amazon)
    Recommended Dose: Work up to 1 dropper full twice daily or 1 scoop 2-3 times daily
  14. L. theanine or GABA - l. theanine is an amino acid that is a precursor to GABA, a calming neurotransmitter. While these are not directly natural anti-histamines, they do help to calm and balance the nervous system which in turn helps to lower MCA. These are excellent tools to reduce anxiety, irritability, depression, insomnia, and nervous system overstimulation.
    Recommended Brand: Pure Encapsulations GABA or L-theanine
    Recommended Dose: GABA - 700mg up to 3 times/day; l-theanine - 250-500 up to 3 times/day
  15. Licorice Root or DGL -either of these forms of licorice root can provide natural anti-histamine support, they work on H2 receptors and can be helpful for symptoms like: flushing, GERD/reflux/heartburn, and throat inflammation.
    Recommended Brand: Designs for Health DGL Synergy Chewable Tablets, Vital Nutrients DGL Powder, or Pure Encapsulations DGL Plus
    Recommended Dose: Up to 1 chewable just after each meal + at bedtime or 1 scoop powder 3 times daily

You can order these supplements at 20% off retail pricing by accessing my online supplement dispensary and setting up an account - just click the button below.

These go-to, natural mast cell stabilizers can be used in combination with pharmaceuticals like ketotifen, cromolyn, singular, and over the counter anti-histamines like Benadryl if needed. I highly recommend working with an experienced practitioner who can help you choose the products that meet your needs best.

Always keep in mind these anti-histamines and mast cell stabilizers are not going to fix the underlying, or root problem(s) that are causing the MCA symptoms. They will simply help to lower reactions and calm the immune response down so that you can start to treat the underlying reasons your mast cells are over-stimulated in the first place.

If you want to learn more about my approach for reducing MC reactions and improving root cause treatment tolerance and effectiveness,check out my free online webinar.


  1. SharmaSC, Sharma S, Gulati OP, “Pycnogenolinhibits the release of histaminefrom mast-cells,”PhytotherRes. 2003 Jan;17(1):66-99
  2. Kimata M,ShichijoM, Miura T, Serizawa I, Inagaki N, Nagai H. Effects of luteolin,quercetin andbaicalein on immunoglobulin E-mediated mediator release from human culturedmastcells.ClinExpAllergy. 2000b;30:501–508. [PubMed]
  3. Park HH, Lee S, Son HY, Park SB, Kim MS, Choi EJ, et al. Flavonoids inhibit histaminerelease andexpression ofproinflammatory cytokinesin mast-cells. Arch Pharm Res.2008;31:1303–1311.[PubMed]
  4. Kim B-R,SeoH-S, Ku J-M, et al.Silibinininhibits the production of pro-inflammatorycytokines throughinhibition of NF-κB signaling pathway in HMC-1 human mast-cells.Inflammation. Research. 2013;62(11):941-950. doi:10.1007/s00011-013-0640-1.
  5. ChapowalA.PetasitesStudy Group.Randomisedcontrolled trial of butterbur and cetirizinefor treating seasonal allergic rhinitis. BMJ 2002;324:144-6.
  6. Hayes, N. A. and Foreman, J. C. The activity of compounds extracted fromfeverfew onhistamine release from rat mast-cells. J PharmPharmacol1987;39(6):466-470
  7. Hsieh et al. Baicalein inhibits IL-1ß- and TNF-a-induced inflammatory cytokineproduction fromhuman mast-cells via regulation of the NF-?B pathway.ClinMolAllergy. 5: 5. 2007.
  8. TheoharidesTC, Patra P, Boucher W, et al. Chondroitinsulphateinhibitsconnective tissuemast-cells. British Journal of Pharmacology. 2000;131(6):1039-1049. doi:10.1038/ sj.bjp.0703672.
  9. Ro JY, Lee BC, Kim JY, et al. Inhibitory mechanism of aloe singlecomponent (alprogen) on mediator release in guinea pig lung mast-cells activated with specificantigenantibodyreactions. JPharmacolExpTher. 2000;292:114–121. 73.
  10. Kim B-R,SeoH-S, Ku J-M, et al.Silibin ininhibits the production of pro-inflammatorycytokines throughinhibition of NF-κB signaling pathway in HMC-1 human mast-cells.Inflammation. Research. 2013;62(11):941-950. doi:10.1007/s00011-013-0640-1.
  11. KimNH,JeongHJ, Kim HM. Theanine is a candidate amino acid forpharmacological stabilizationof mast-cells. Amino Acids. 2011;42:1609–1618.
  12. Theoharides,TheoharisC., and LeonardBielory. “Mast-cells and mast-cell mediatorsas targetsof dietary supplements.” Annals of Allergy, Asthma & Immunology 93.2 (2004): S24-S34.


Sharon Carpenter

9/28/2018 01:19:35 pm

Billie, your info is short and powerful. I really love what your putting out and gain from the knowledge. I like it better than Chris Kresser.
Great job.


Billie Shellist

10/1/2018 11:37:25 am

Thanks for the great feedback Sharon!



11/19/2018 03:14:36 pm

Do you have a recording of the webinar?


Billie Shellist

11/21/2018 07:21:56 am

(Video) Top 7 Mast Cell Activation Syndrome Triggers You Should Avoid

Hi Justin, Yes I do have the webinar recorded. Here is a link to listen to the recording:https://www.functionaldiagnostichealing.com/mcas-webinar-recordings.html



12/29/2019 10:14:35 pm

Did you ever make that blog post about common root causes of MCAS/Histamine Intolerance?


Billie Shellist

12/30/2019 06:16:52 am

Hello S - I dont have a blog, but do have a recorded webinar on MCAS that includes a complete discussion on the root causes. Click this link here to check that out:https://www.functionaldiagnostichealing.com/mastcellactivationwebinar.html


Penny Jean Wilson

5/16/2020 02:16:23 pm

I have been doing a ton of research into mast cell stabilizers in covid 19. I would love to share some info with you. I am a retired ccu nurse with mast cell activation disorder and eosinophilic asthma with multiple respiratory failures so I was at huge risk for critical covid19 infection and boy did I get it. I vlogged my entire journey on facebook and have now dedicated most of my time to track this little virus down to it's first actions when it enters the lungs....as far as I can tell...mast cell activation. This mast cell activation normally would be exactly whats needed to fight this thing, but the virus exploits the chemicals created in the mast cell reaction to prime the cells for entry and to damage dendritic cells so they can't sound the alarm for help. Then the virus sets up house like a non-paying unevictable tenant. I would love to hear your thoughts.



5/17/2020 06:41:25 am

HI Penny,
I'd love to hear more about your story and the information you've learned. Please email me at functionaldiagnostichealing@gmail.com


Amy Plath

5/26/2020 06:05:39 am

Penny - I would love to hear your ideas, too. Can you link your vlog or possibly contact me at plathtones@gmail.com. Many thanks!



8/4/2020 08:18:37 pm

Penny, I'd love to hear more from you about this as well. My medical training is limited (emergency medicine) so I don't have near the insight that you do. But I have MCAD and have contracted COVID twice. It has been quite the journey, to say the least. And the mast cell impact has been substantial. I searched for you in Facebook, because I'd love to see your vlogs, but wasn't able to find you. And you don't seem to be in the MCAS/COVID Facebook group either. If you're willing, would you reach out and share your vlog? I'd like to compare stories. venmk@hotmail.com is the best way to reach me.


christopher tishlias

1/11/2021 11:39:58 pm

Hi Pennie,

I have MCAs and got Covid as well in March & am still dealing with the suffering from that. Would love to share stories, info, & guidance. ctishlias@yahoo.com


Thanh Tran

11/27/2021 06:25:48 pm

(Video) Histamine and Antihistamines, Pharmacology, Animation

Hi, Penny. How are you?
I can't find you on Facebook. I have been suffering from Covid MCAS since July of last year and it's getting worse. Lost a ton of weight (unintentionally), can't eat anything without feeling sick to the stomach, bedridden atm. Would love to hear from you.



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Amy Smith

11/14/2020 12:55:22 pm

I desperately need help with histamine intolerance/possibly mast cell activation syndrome. I am fighting for my life right now, and I need help figuring out what to do to get better. I need help immediately please. I have been to four doctors, the ER, tried multiple approaches, and I am not getting better. i seem to be sensitive to everything. I know that you are booked up, but I am begging for help. I know that you want to help people...please help me. I would love to have a consultation as soon as possible. I am just struggling so much! Thank you for your time and consideration!



1/5/2021 08:50:58 am

Which of these natural antihistamines can be taken with salicylat intolerance?


Billie Shellist

1/6/2021 07:55:30 am

If you are salicylate sensitive, the items I recommend starting with are DAO, No-Fenol Enzymes, Nettle Leaf, Vitamin C, Pycnogenol, Baikal Skullcap, L-theanine and GABA. The ones you are less likely to tolerate would be quercetin and luteolin.


2/3/2021 09:49:07 am

Hey Billie!

Thanks for the great post! Though I'm already on several of these I love reading the description and making me feel more empowered with reinforcing the info in my mind!


2/19/2021 01:43:59 pm

phenol in mirica .dr tc said lutoline very little.so whT phneol cause damage in lutoline.
also can gaba supplements work



2/27/2021 12:15:52 am

Is epstein barr considered a retrovirus?


Billie Shellist

3/3/2021 07:18:50 am

No, EBV is not a retrovirus


(Video) Best Natural Antihistamines For Allergy Relief, seasonal allergies, hay fever and allergic rhinitis


2/28/2021 07:29:01 pm

What was the homeopathic you suggested in your video. Its hard to understand it clearly. Most homeopathics have odd names so im trying to be sure I heard what I heard. Lol


Billie Shellist

3/3/2021 07:19:37 am

The homeopathic I talked about that can help modulate immune function and reduce the cell danger response is Suramin Homeopathic



1/26/2022 02:27:35 pm

What potency for the Suramin homeopathic? Thanks

Elle Bee

3/12/2021 05:01:43 pm

I am wondering if any of these are made using corn. Corn is an allergen, severe. Also, if you are allergic to things like apples and latex foods... are any of these things you can have?


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Leonard siracusa

5/8/2021 11:14:32 pm

I am pretty sure I have mast cell. At the least a severe histamine intolerance but I get terrible panic attacks from breathing cleaning products and scents, and I have had terrible issues since I had a reaction to an antibiotic two years ago. My biggest issue that I worry about is my heart rate gets funny , it really runs fast. Exercise seems to be a trigger, some foods. And my bp seems to be all over and Sensitive. Any of these other than maybe l-Theanine that might be used to help a histamine induced rapid heart rate?


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(Video) Management of Mast Cell Activation Syndrome (MCAS) Presented by David Saperstein, M.D.

7/25/2021 07:28:27 pm

Do you know if DGL licorice contains salicylates? I know that regular licorice does, and am wondering if the removal of glycyrrhizin makes it safe. I'm looking for something to treat gastritis that is low salicylate and oxalate and it's proving very difficult. I have the gastritis from a bad reaction to salicylates.


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12/6/2021 12:54:14 pm

Can Enzymedica digestive enzymes be taken along with No-Fenol enzyme. Please kindly let me know. Thanks



12/12/2021 05:35:02 am



3/28/2022 06:54:17 am

I really like to visit your Product review. It is very useful to everyone


    15 Natural Anti-Histamines & Mast Cell Stabilizers (2)

    Billie Shellist, FDN-P

    I practice functional nutrition, an approach that allows me to look at your entire health history and help you find the "root causes" of your chronic health complaints.

    ​This cuts out the trial and error process and helps youget real symptomrelief and resolution!

    Food is medicine andknowledge is power -I hope you enjoy my anti-inflammatory recipes which are gluten, dairy, and soy free as well as very low grain and sugar.

    If you'd like to heal from the root cause(s) of your chronic symptoms, try starting with a complimentary 15-minute consultation. Click here to requestyour freesession.


    Anti Inflammatory Foods



    Food Sensitivities

    Gluten Free Recipes
    Grain Free Recipes

    Histamine Intolerance/MCAS
    Holiday Recipes
    Hormonal Health
    Kid Friendly
    Main Dishes
    Self Care Practices

    Special Diets
    Vegan Recipes
    Vegetarian Recipes
    Weight Management

    (Video) Is Histamine Intolerance The Cause Of Your Mysterious Symptoms?


How can I calm my mast cells naturally? ›

How to calm a mast cell activation? Avoid foods high in histamines such as leftover foods, alcohol, cured meats like bacon, ham, and canned fish. It is essential to avoid extreme temperatures, molds, medications that release histamine at high levels, and common preservatives like sodium benzoate.

What is the best antihistamine for mast cell? ›

Drugs that modulate the symptoms of mast cell activation

Non-sedating H1 antihistamines, eg cetirizine, loratadine, fexofenadine, are often preferred.

Which antihistamines stabilize mast cells? ›

Note: The H1 and H2 antihistamines are necessary to stabilize receptors on the mast cell.

How do you heal MCAS naturally? ›

12 Tips for Living With Mast Cell Activation Syndrome
  1. Adopt a low histamine diet. ...
  2. Avoid triggers of MCAS (non-food items) ...
  3. Work on your gut health. ...
  4. Stabilize mast cell mediator release. ...
  5. Use H1 and H2 blockers every 12 hours. ...
  6. Block and reduce nighttime histamine release. ...
  7. Treat existing infections.
Nov 28, 2017

How do you flush histamine out of your body? ›

The best way to clear histamine from the body is to start an elimination diet that involves only eating and drinking substances that contain low amounts of histamine.

Is magnesium a mast cell stabilizer? ›

Magnesium[edit | edit source]

Like Vitamin C, magnesium is a co-factor in the production of diamine oxidase. Magnesium deficiency has been seen to increase mast cell production in some cases; therefore magnesium supplementation may be helpful in controlling mast cell division.

How do you calm a mast cell flare up? ›

Treatments can include:
  1. H1 or H2 antihistamines. These block the effects of histamine, which is one of the primary mediators that mast cells release. ...
  2. Aspirin. This may decrease flushing.
  3. Mast cell stabilizers. ...
  4. Antileukotrienes. ...
  5. Corticosteroids.

Is Quercetin a mast cell stabilizer? ›

Quercetin is similar to cromolyn in its mechanism of action. Both are basophil and mast cell stabilizers.

What blocks histamine release? ›

Mast cell stabilizers prevent the release of mast cell mediators such as histamine through stabilization of the mast cell membrane. These agents are most effective when used prior to antigen exposure. Sodium cromoglycate (cromolyn sodium) has now been available in an intranasal format OTC for almost 10 years.

Is Quercetin a histamine blocker? ›

Quercetin is a naturally occurring polyphenol flavonoid which is rich in antioxidants. It has anti-allergic functions that are known for inhibiting histamine production and pro-inflammatory mediators.

Is turmeric a mast cell stabilizer? ›

"The active component of turmeric is curcumin, which has anti-inflammatory properties, and its anti-allergic properties are due to inhibition of histamine release from mast cells," Dr. Galowitz says.

Does Ashwagandha lower histamine? ›

Ashwagandha – an Ayurvedic remedy known as an adaptogenic herb that modulates the body's response to stress. Withaferin A is a compound found in ashwagandha that has been shown to prevent mast cells from releasing histamine and other inflammatory mediators. Vitamin D – usually best at higher doses.

Does B12 increase histamine? ›

Folic acid (with vitamin B12) can help to raise the histamine level.

How do you stop histamines naturally? ›

Vitamin C is a natural antihistamine, which means it can lower histamine levels and mitigate allergic reactions and symptoms. Consume plenty of Vitamin C rich foods, like tropical fruits, citrus fruits, broccoli and cauliflower, and berries.

Is there a natural antihistamine? ›

Natural antihistamines may help you control your seasonal allergies. Common ones are stinging nettle, vitamin C, quercetin, butterbur, bromelain, and probiotics. Some alternative practices—such as acupuncture, nasal irrigation, and exercise—may also help you manage symptoms.

What is the fastest way to reduce histamine? ›

Antihistamines block histamine activity, seeking to stop the allergic reaction. Many allergy medications on the shelves of your local drugstore work as antihistamines. But there are also certain foods and plant extracts that may similarly block the effects of histamine.

Does zinc lower histamine? ›

The zinc chelator N,N,N′,N′-tetrakis(2-pyridylmethyl)ethylenediamine (TPEN) inhibits the release of histamine, the production of cytokines, and the secretion of lipid mediators in mast cells, and zinc supplementation rescues these inhibitory effects.

Does vitamin D help with MCAS? ›

Recent studies have suggested vitamin D may play a role in suppression of mast cell activation and have an immunomodulatory effect. With MCAS, one may consider vitamin D deficiency when patients' symptoms continue despite traditional therapies targeting mast cell mediator release.

How much quercetin is in a mast cell? ›

For patients with mast cell activation syndrome (MCAS), taking up to 500mg of quercetin 30 to 40 minutes before eating can substantially reduce histamine release during meals.

What does a mast cell flare feel like? ›

Please note that any patient with a mast cell disease can potentially react to any trigger, and triggers can change over the course of the disease.
Symptoms and Triggers of Mast Cell Activation.
MOUTHItching, swelling of lips and/or tongue
THROAT*Itching, tightness/closure, hoarseness
SKINItching, hives, redness, swelling
GUTVomiting, diarrhea, cramps
2 more rows

Are Bananas high in histamine? ›

Some foods don't contain high levels of histamine, but they are “histamine liberators” that promote the release of the chemical in our body. These include: Pineapples. Bananas.

Why is my body producing too much histamine? ›

Histamine is a chemical created in the body that is released by white blood cells into the bloodstream when the immune system is defending against a potential allergen. This release can result in an allergic reaction from allergy triggers such as pollen, mold, and certain foods.

Who should not take quercetin? ›

Pregnant women, breastfeeding women, and people with kidney disease should avoid quercetin. At doses greater than 1 g per day, there have been reports of damage to the kidneys.

Is Turmeric high in histamine? ›

​ Turmeric is likely suitable for a low histamine diet. Turmeric is likely low in histamine and other amines and does not trigger release of the body's natural histamine. Every person has unique dietary triggers.

What foods cause mast cell activation? ›

There are foods that patients with mast cell disease seems to be more reactive to overall. These include but are not limited to: Monosodium Glutamate (MSG), alcohol, shellfish, artificial food dyes and flavorings, food preservatives, pineapples, tomatoes & tomato based products, and chocolate.

Is coffee high in histamine? ›

Coffee is actually high in histamine and can result in an allergic reaction but it is different to a typical allergy mechanism. With caffeine, the histamine contained in the coffee causes an inflammatory reaction that can be affect some people with caffeine and histamine intolerances.

Is Cinnamon high in histamine? ›

While not one of the inherently high histamine spices, Cinnamon contains compounds called benzoates that trigger histamine release. So, cinnamon is a histamine stimulator and one you should approach with caution if you have histamine intolerance.

Are carrots high in histamine? ›

Carrot is likely low in histamine and other amines and does not trigger release of the body's natural histamine. Every person has unique dietary triggers. Your reaction to carrot may be different than someone else's.

What is the most powerful natural antihistamine? ›

1. Stinging nettle. A common herb in natural medicine, stinging nettle, may also be a natural antihistamine. In a 2000 study, 58 percent of participants found their symptoms relieved with the use of freeze-dried nettles, and 69 participants rated it better than the placebo.

What is the most powerful antihistamine? ›

Cetirizine is the most potent antihistamine available and has been subjected to more clinical study than any other.

Does magnesium lower histamine? ›

Treating children who have ADHD with magnesium decreased their hyperactivity 15. Magnesium is also needed to make the enzyme, DAO, which mops up histamine when it's been released, if you can't make DAO, histamine levels in the blood increase 16.

Is ginger a mast cell stabilizer? ›

Focus on nutrients and foods known to stabilize mast cells: Many nutrients, including selenium (21) and vitamin C (22), have been shown to stabilize mast cells. A number of herbs and spices, like holy basil (23), peppermint (24), ginger (25), thyme (26), and turmeric (27) also have this effect.

What foods are natural antihistamines? ›

People with allergies may find relief by using natural plant extracts and foods that act as antihistamines.
1. Vitamin C
  • bell peppers.
  • broccoli.
  • cantaloupe melon.
  • cauliflower.
  • citrus fruits.
  • kiwifruit.
  • strawberries.
  • tomatoes and tomato juice.
Oct 8, 2018

Is aloe vera a mast cell stabilizer? ›

Collectively, aloe-emodin is a highly potent mast cell stabilizer. By directly activating MCU, it decreases Ca2+[c] level to suppress mast cell degranulation.

Who shouldnt take ashwagandha? ›

Certain groups of people should avoid using ashwagandha, including those who are pregnant or breastfeeding and those who have medical conditions like diabetes, high or low blood pressure, stomach ulcers, autoimmune disease, or thyroid disorders.

What tea is low histamine? ›

You can still have a cup of tea if you have histamine intolerance but stick to green or white tea since it's not fermented like black tea. Herbal teas are another option. Ginger tea and moringa tea may offer benefits since they reduce inflammation and histamine release.

What herbs are good for histamine intolerance? ›

Nettles. Nettle leaf is a natural antihistamine that naturally blocks histamine production. It can be made in to a tincture or tea, but for allergy relief, capsules made from dried nettle leaves are the most effective option.

Does vitamin C block histamine? ›

Vitamin C acts as a natural antihistamine by reducing the amount of histamine your body produces in response to an allergen. It might help reduce mild symptoms like sneezing, runny nose, congestion, and watery eyes due to allergic rhinitis.

Does Omega 3 help with histamine intolerance? ›

Omega 3 – pure omega 3 fish oil can be helpful at reducing the inflammation triggered by histamine. Avoid fermented cod liver oil. Anti-inflammatory polyphenols including Resveratrol and Turmeric which help to stabilise mast cells.

Does vitamin C stabilize mast cells? ›

Vitamin C is important in mast cell activation disorder for its role in the breakdown of histamine and as a mast cell stabilizer. Vitamin C is also a co-factor in collagen synthesis, making it a potentially important nutrient in Ehlers-Danlos syndrome and other connective tissue disorders.

How do you calm a mast cell flare up? ›

Treatments can include:
  1. H1 or H2 antihistamines. These block the effects of histamine, which is one of the primary mediators that mast cells release. ...
  2. Aspirin. This may decrease flushing.
  3. Mast cell stabilizers. ...
  4. Antileukotrienes. ...
  5. Corticosteroids.

What triggers mast cell activation? ›

When triggered, these mast cells release substances that can cause signs and symptoms similar to those of an allergic reaction and, sometimes, severe inflammation that may result in organ damage. Common triggers include alcohol, spicy foods, insect stings and certain medications.

How do you treat mast cell activation? ›

There is no cure for the condition. You will need to avoid triggers and use medications. If you have anaphylactic reactions, your doctor might also give you an auto-injector epinephrine pen to use in emergencies.

Does vitamin C stabilize mast cells? ›

Vitamin C is important in mast cell activation disorder for its role in the breakdown of histamine and as a mast cell stabilizer. Vitamin C is also a co-factor in collagen synthesis, making it a potentially important nutrient in Ehlers-Danlos syndrome and other connective tissue disorders.

How can I reduce histamine naturally? ›

Some foods low in histamine include:
  1. fresh meat and freshly caught fish.
  2. non-citrus fruits.
  3. eggs.
  4. gluten-free grains, such as quinoa and rice.
  5. dairy substitutes, such as coconut milk and almond milk.
  6. fresh vegetables except tomatoes, avocados, spinach, and eggplant.
  7. cooking oils, such as olive oil.

Does B12 increase histamine? ›

Folic acid (with vitamin B12) can help to raise the histamine level.

Are Bananas high in histamine? ›

Some foods don't contain high levels of histamine, but they are “histamine liberators” that promote the release of the chemical in our body. These include: Pineapples. Bananas.

What does a mast cell reaction feel like? ›

Dry eyes, red itchy and red burning, runny nose, and inflammation ulcers of the mouth may be seen in the head and neck organ system. In regard to the chest and heart, chest discomfort, rapid heartbeats, redness, flushing of the skin, sudden dizziness, hot flashes, and blood pressure surges may be seen.

How long do mast cell flares last? ›

Some people with systemic mastocytosis may experience episodes of severe symptoms that last 15-30 minutes, often with specific triggers such as physical exertion or stress. Many people do not have any problems.

What does a mast cell rash look like? ›

You might have a red and itchy rash if there are too many mast cells in your skin. You could get hives or have a rash that looks like freckles. If you rub the rash, it can get red and swollen. Sometimes the mast cells collect at one spot in your skin and cause one large lump.


1. The Root Causes of Mast Cell Activation Syndrome (MCAS) and How to Restore Order to the Mast Cells
(Restorative Chiropractic & Functional Wellness Center)
2. Help for long Covid - foods to avoid - supplements to take - with Dr Tina Peers, specialist in MCAS
(nicola haseler)
3. Foods Rich in: Antihistamines
(Ryan Taylor)
4. How Quercetin & Vitamin C Are GREAT Antihistamines!
(Dr. Susan E. Brown)
5. Dr. Peter Vadas - CME Presentation: Mast Cells Gone Wild - Mast Cell Activation Disorders
(The ILC Ehlers Danlos & Chronic Pain Foundation)
6. How To Treat Mast Cell Activation Syndrome | Ask Eric Bakker
(Eric Bakker - The Naturopath)

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